Deletion of mesencephalic astrocyte-derived neurotrophic factor delays and damages the development of white pulp in spleen

In this study, we detected MANF expression in spleen tissues and found that MANF was expressed in the red pulp and marginal zone. Additionally, MANF was localized in the CD68+ and CD138+ cells of adult rat spleen tissues, but not in the CD3+ cells. We performed immunohistochemical staining to detect MANF expression in the spleen tissues of rats that were different ages, and we found that MANF+ cells were localized together in the spleen tissues of rats that were 1-4 weeks old. MANF was also expressed in CD68+ cells in the spleen tissues of rats and mice. Furthermore, we found that MANF deficiency inhibited white pulp development in MANF knockout mice, thus indicating that MANF played an important role in the white pulp development of rodent spleen tissues.PMID:38159526 | DOI:10.1016/j.imbio.2023.152778

Source: Immunobiology - December 30, 2023 Category: Allergy & Immunology Authors: Chengyue Zhou Dan Han Hui Fang Dake Huang Heping Cai Yujun Shen Yuxian Shen Jun Liu Source Type: research