IFN- β Pretreatment Alleviates Allogeneic Renal Tubular Epithelial Cell-Induced NK Cell Responses via the IRF7/HLA-E/NKG2A Axis

In conclusion, IFN-β pretreatment could activate HLA-E and PD-L1 transcription through the JAK/STAT/IRF7 pathway and then could protect renal tubular epithelial cells from allogeneic immune attack mediated by NK cells.PMID:38149913 | DOI:10.4049/jimmunol.2200941

Source: Journal of Immunology - December 27, 2023 Category: Allergy & Immunology Authors: Xing Zhang Junni Wang Mowang Wang Mengbao Du Jianghua Chen Limengmeng Wang Jianyong Wu Source Type: research