Genetic Influences on Alcohol Sensitivity: a Critical Review

We describe the advances that these studies have made in terms of further demonstrating the heritability of alcohol sensitivity along with limitations in terms of identifying genome-wide significant loci and what we see as the primary challenges facing such studies. We conclude with suggestions for future research and what could be achieved with larger samples.SummaryProgress in the molecular genetic study of AUD and related phenotypes is being made. Nonetheless, significant efforts are needed to conduct GWAS of more specific AUD risk factors, such as alcohol sensitivity, to more fully understand how individual genetic loci contribute to AUD risk. In doing so, we will be better positioned to understand the etiologic relations between these AUD risk factors and how their confluence ultimately increases risk for AUD.
Source: Current Addiction Reports - Category: Addiction Source Type: research