Marein Ameliorates Myocardial Fibrosis by Inhibiting HIF-1 α and TGF-β1/Smad2/3 Signaling Pathway in Isoproterenol-stimulated Mice and TGF-β1-stimulated Cardiac Fibroblasts

CONCLUSION: Marein might exert a protective function in isoproterenol-stimulated myocardial fibrotic mice and TGF-β1-stimulated CFs, which might result from the reduction of TGF-β1 induced HIF-1α expression, then inhibiting p-Smad2/3 and Smad2/3 expressions.PMID:38151839 | DOI:10.2174/0113816128282062231218075341

Source: Current Pharmaceutical Design - December 28, 2023 Category: Drugs & Pharmacology Authors: Guanghao Niu Ying Zhao Huafeng Song Quan Song Xiaoyun Yin Zengyan Zhu Junchi Xu Source Type: research