Small airway fibroblasts from Chronic Obstructive Pulmonary Disease patients exhibit cellular senescence

CONCLUSIONS: These data suggest COPD SAF are senescent and may be associated with fibrotic properties and mitochondrial dysfunction. Further understanding cellular senescence in SAF may lead to potential therapies to limit SAD progression.PMID:38150543 | DOI:10.1152/ajplung.00419.2022

Source: Am J Physiol Lung Ce... - December 27, 2023 Category: Respiratory Medicine Authors: Catherine L Wrench Jonathan R Baker Sue Monkley Peter S Fenwick Lynne Murray Louise E Donnelly Peter J Barnes Source Type: research