Modulation of glucocorticoid resistance in pediatric T-cell Acute Lymphoblastic Leukemia by increasing BIM expression with the PI3K/mTOR inhibitor BEZ235.

CONCLUSIONS: Our data support the further investigation of agents targeting the PI3K/mTOR pathway to modulate glucocorticoid resistance in T-ALL.
PMID: 26080839 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - June 16, 2015 Category: Cancer & Oncology Authors: Hall CP, Reynolds CP, Kang MH Tags: Clin Cancer Res Source Type: research