Cardiopulmonary Bypass Circuit Obstruction and Urgent Replacement After the Administration of Andexanet Alfa

Thrombus occlusion in the cardiopulmonary bypass (CPB) circuit is a life-threatening adverse event. Herein, the authors present a case of Stanford type A aortic dissection in which the CPB circuit became completely occluded intraoperatively, necessitating immediate circuit replacement. The patient preoperatively had been prescribed edoxaban, a direct oral anticoagulant (DOAC). Due to the evident preoperative tendency for bleeding, the authors decided to administer andexanet alfa to antagonize the effects of edoxaban.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Case Report Source Type: research