Real-world effectiveness of full and booster mRNA vaccination for coronavirus disease 2019 against disease severity during the delta- and omicron-dominant phases: A propensity score-matched cohort study using the nationwide registry data in Japan

CONCLUSIONS: Full vaccination reduced disease severity during the delta- and omicron-dominant phases; booster vaccination did not further enhance the protective effects against disease progression during the omicron-dominant phase compared to full vaccination. Future vaccine strategies and policy decisions should consider preventing infection or disease progression in the target population, as well as the characteristics of the dominant variant in that phase.PMID:38123439 | DOI:10.1016/j.jmii.2023.12.002

Source: Journal of Microbiology, Immunology, and Infection - December 20, 2023 Category: Microbiology Authors: Tetsuya Suzuki Yusuke Asai Shinya Tsuzuki Hidetoshi Nomoto Nobuaki Matsunaga Eiichi N Kodama Kayoko Hayakawa Norio Ohmagari Source Type: research