Spatial gene expression profiling unveils immuno-oncogenic programs of NF1-associated peripheral nerve sheath tumor progression

CONCLUSIONS: If validated prospectively in future studies, these signatures may serve as molecular diagnostic tools to augment conventional histopathological diagnosis by identifying neurofibromas at high risk of undergoing malignant transformation, facilitating risk-adapted care.PMID:38127282 | DOI:10.1158/1078-0432.CCR-23-2548

Source: Clinical Cancer Research - December 21, 2023 Category: Cancer & Oncology Authors: Dana K Mitchell Breanne Burgess Emily White Abbi E Smith Elizabeth A Sierra Potchanant Henry Mang Brooke Rodriguez Qingbo Lu Shaomin Qian Waylan Bessler Xiaohong Li Li Jiang Kylee Brewster Constance Temm Andrew Horvai Eric A Albright Melissa L Fishel Chri Source Type: research