Extracellular vesicles of Weizmannia coagulans lilac-01 reduced cell death of primary microglia and increased mitochondrial content in dermal fibroblasts in vitro

Biosci Biotechnol Biochem. 2023 Dec 20:zbad175. doi: 10.1093/bbb/zbad175. Online ahead of print.ABSTRACTWe investigated the properties of extracellular vesicles from the probiotic Weizmannia coagulans lilac-01 (Lilac-01EVs). The phospholipids in the Lilac-01EV membrane were phosphatidylglycerol and mitochondria-specific cardiolipin. We found that applying Lilac-01EVs to primary rat microglia in vitro resulted in a reduction in primary microglial cell death (p < 0.05). Lilac-01EVs, which contain cardiolipin and phosphatidylglycerol, may have the potential to inhibit cell death in primary microglia. The addition of Lilac-01EVs to senescent human dermal fibroblasts suggested that Lilac-01 EVs increase the mitochondrial content without affecting their membrane potential in these cells.PMID:38124666 | DOI:10.1093/bbb/zbad175

Source: Bioscience, Biotechnology, and Biochemistry - December 21, 2023 Category: Biochemistry Authors: Kimiko Minamida Toshio Taira Masato Sasaki Ohki Higuchi Xian-Ying Meng Yoichi Kamagata Kazunori Miwa Source Type: research