Human CD34+/dim neutrophil-committed progenitors do not differentiate into neutrophil-like CXCR1  + CD14 + CD16- monocytes in vitro

In this study, by performing a more analytical reevaluation at the phenotypic and molecular levels of the cells generated by NCP2 s and NCP4 s (selected as representatives of NCPs), we categorically exclude that NCPs generate neutrophil-like CXCR1 + CD14 + CD16-monocytes. Rather, we provide substantial evidence indicating that the cells generated by NePs/alias "early neutrophil-committed progenitors" are neutrophilic cells at different stage of maturation, displaying moderate levels of CD14, instead of neutrophil-like CXCR1 + CD14 + CD16-monocytes as pointed by Ikeda and coworkers. Hence, the conclusion that NePs/alias "early neutrophil-committed progenitors" aberrantly differentiate into neutrophil-like monocytes derives, in our opinion, from data misinterpretation.PMID:38114064 | DOI:10.1093/jleuko/qiad160
Source: Journal of Leukocyte Biology - Category: Hematology Authors: Source Type: research