Molecules, Vol. 29, Pages 64: Effects of Silybum marianum L. Seed Extracts on Multi Drug Resistant (MDR) Bacteria

Molecules, Vol. 29, Pages 64: Effects of Silybum marianum L. Seed Extracts on Multi Drug Resistant (MDR) Bacteria Molecules doi: 10.3390/molecules29010064 Authors: Shimaa El-Sapagh Nanis G. Allam Mohamed Nour El-Dein El-Sayed Asmaa Ahmed El-Hefnawy Grażyna Korbecka-Glinka Awad Y. Shala Wound infections became a great challenge, especially after the emergence of bacterial resistance to commonly used antibiotics. Medicinal plants can be the source of alternative antibacterial agents effective against multi drug resistant (MDR) bacteria. This research aimed to evaluate the effectiveness of different Silybum marianum seed extracts in fighting MDR bacteria that infect wounds. First, thirty purified bacterial cultures obtained from superficial, infected wounds were subjected to antibiotic sensitivity tests. The selected MDR isolates were then used to test the antimicrobial effects of different S. marianum seed extracts. The most potent extract was evaluated for its impact on the ultrastructure of the cells of sensitive bacterial isolates using transmission electron microscopy (TEM). The bioactive ingredients of this extract were analyzed by means of gas chromatography–mass spectroscopy (GC–MS). Then, in-silico absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties were predicted for the main components. The results indicated that four out of 30 bacterial isolates were considered MDR bacteria. Primary morpholog...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research