Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism

CONCLUSION: These results demonstrate the existence of a dynamic equilibrium between CSF1, the mononuclear phagocyte system and control of liver:body weight ratio, which in turn controls systemic metabolic homeostasis. This novel macrophage regulatory axis has the potential to promote fat mobilisation, without changes in appetence, which may have novel implications for managing metabolic syndrome.PMID:38117267 | DOI:10.1152/ajpendo.00347.2023

Source: American Journal of Physiology. Endocrinology and Metabolism - December 20, 2023 Category: Physiology Authors: Sahar Keshvari Jesse J R Masson Michelle Ferrari-Cestari Liviu-Gabriel Bodea Fathima Nooru-Mohamed Brian W C Tse Kamil A Sokolowski Lena Batoon Omkar L Patkar Mitchell A Sullivan Hilmar Ebersbach Cian Stutz Robert G Parton Kim M Summers Allison R Pettit D Source Type: research