CircPHKB decreases the sensitivity of liver cancer cells to sorafenib via miR-1234-3p/CYP2W1 axis

In this study, we provided initial evidence demonstrating that circPHKB, a novel circRNA markedly overexpressed in sorafenib-treated liver cancer cells, attenuated the sensitivity of liver cancer cells to sorafenib. Mechanically, circPHKB sequestered miR-1234-3p, resulting in the up-regulation of cytochrome P450 family 2 subfamily W member 1 (CYP2W1), thereby reducing the killing effect of sorafenib on liver cancer cells. Moreover, knockdown of circPHKB sensitized liver cancer cells to sorafenib in vivo. The findings reveal a novel circPHKB/miR-1234-3p/CYP2W1 pathway that decreases the sensitivity of liver cancer cells to sorafenib, suggesting that circPHKB and the axis may serve as promising targets to improve the therapeutic efficacy of sorafenib against liver cancer.PMID:38113974 | DOI:10.1016/j.ygeno.2023.110764

Source: Genomics - December 19, 2023 Category: Genetics & Stem Cells Authors: Lingxi Chen Hanxi Xiao Yaran Wu Dongjing Yan Meihua San Liangbo Sun Xiaojing Yan Dong Liu Tao Li Yang Zhang Li Xiang An Chen Shuhui Li Wei Xiang Zhenhong Ni Fengtian He Mingzhen Yang Jiqin Lian Source Type: research