14-3-3- η interacts with BCL-2 to protect human endothelial progenitor cells from ox-LDL-triggered damage

In this study, we observed that the expression of 14-3-3-η and BCL-2 were downregulated in ox-LDL-treated EPCs. Overexpression of 14-3-3-η in ox-LDL-treated EPC significantly increased BCL-2 level, while knockdown of BCL-2 reduced 14-3-3-η expression and mitigated the protective effect of 14-3-3-η on EPCs. In addition, we discovered that 14-3-3-η colocalizes and interacts with BCL-2 in EPCs. Taken together, these data suggest that 14-3-3-η protects EPCs from ox-LDL-induced damage by its interaction with BCL-2.PMID:38100125 | DOI:10.1002/cbin.12105
Source: Cell Biology International - Category: Cytology Authors: Source Type: research