Tertiary lymphoid structures, a historical reappraisal

Tissue Cell. 2023 Dec 10;86:102288. doi: 10.1016/j.tice.2023.102288. Online ahead of print.ABSTRACTTertiary lymphoid structures (TLSs) are accumulations of lymphoid cells within non-lymphoid organs that share the cellular compartments, spatial organization, vasculature, chemokines, and function with secondary lymphoid organs, especially lymph nodes. TLSs are organized into a separate T cell and B cell compartments which contain germinal centers with follicular dendritic cells. In most cases, TLSs contain Peripheral Node addressin (PNAD) expressing high endothelial venules (HEVs). TLSs have been described in various mouse models of inflammation and are associated with a wide range of autoimmune diseases. Other than these, TLSs have been described in chronic allograft rejection and cancer.PMID:38101028 | DOI:10.1016/j.tice.2023.102288
Source: Tissue and Cell - Category: Cytology Authors: Source Type: research