Repetitive hypoxic preconditioning induces an immunosuppressed B cell phenotype during endogenous protection from stroke

Conclusions: Collectively, our data characterize an endogenous neuroprotective phenotype that utilizes adaptive immune mechanisms pre-stroke to protect the brain from injury post-stroke. Future studies to validate the role of B cells in minimizing injury and promoting central nervous system recovery, and to determine whether B cells mediate an adaptive immunity to systemic hypoxia that protects from subsequent stroke, are needed.
Source: Journal of Neuroinflammation - Category: Neurology Authors: Source Type: research