Repetitive hypoxic preconditioning induces an immunosuppressed B cell phenotype during endogenous protection from stroke
Conclusions:
Collectively, our data characterize an endogenous neuroprotective phenotype that utilizes adaptive immune mechanisms pre-stroke to protect the brain from injury post-stroke. Future studies to validate the role of B cells in minimizing injury and promoting central nervous system recovery, and to determine whether B cells mediate an adaptive immunity to systemic hypoxia that protects from subsequent stroke, are needed.
Source: Journal of Neuroinflammation - Category: Neurology Authors: Nancy MonsonSterling OrtegaSara IrelandAnouk MeeuwissenDing ChenErik PlautzErin ShubelXiangmei KongMin LiLaura FreriksAnn Stowe Source Type: research
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