Irisin limits amyloid- β buildup in Alzheimer's disease

Trends Endocrinol Metab. 2023 Dec 14:S1043-2760(23)00245-X. doi: 10.1016/j.tem.2023.11.006. Online ahead of print.ABSTRACTMounting evidence suggests that physical exercise protects the brain against neurodegenerative disease. In a recent paper in Neuron, Kim et al. reported that the exercise-induced hormone irisin curbs amyloid-β buildup by promoting secretion of astrocyte-derived neprilysin. These findings may help explain the neuroprotection by irisin and exercise in Alzheimer's disease.PMID:38101996 | DOI:10.1016/j.tem.2023.11.006
Source: Trends in Endocrinology and Metabolism: TEM - Category: Endocrinology Authors: Source Type: research