PEGylation Strategy for Improving the Pharmacokinetic and Antitumoral Activity of the IL-2 No-alpha Mutein

CONCLUSION: PEG20K was selected as the best modification strategy, to improve the blood circulation time of the IL-2noα with a superior antimetastatic effect achieved with lower doses.PMID:38083887 | DOI:10.2174/0113816128279062231204110410

Source: Current Pharmaceutical Design - December 12, 2023 Category: Drugs & Pharmacology Authors: Marianniz D íaz-Hernández Janoi Chang-Calder ón Miguel Angel Álvarez Ingrid Ruiz Ram írez Olga Lidea Fern ández Saez Armando L ópez Medinilla Carlos Yordan Gonz ález Castillo Claudia Diaz Borges Sum Lai Lozada Chang Kalet Le ón Tania Carmenate Source Type: research