A protective role of nintedanib in peritoneal fibrosis through H19 –EZH2–KLF2 axis via impeding mesothelial-to-mesenchymal transition

ConclusionIn summary, nintedanib disrupts MMT process through regulating H19/EZH2/KLF2 axis and TGF- β/Smad pathway, which laid the experimental foundation for nintedanib in the treatment of PF.

http://link.springer.com/10.1007/s11255-023-03892-8

Source: International Urology and Nephrology - December 14, 2023 Category: Urology & Nephrology Source Type: research