Extracellular vesicles secreted by primary human bronchial epithelial cells reduce < em > Pseudomonas aeruginosa < /em > burden and inflammation in Cystic Fibrosis mouse lung

In this study using a CF mouse model of P. aeruginosa infection we demonstrate that intratracheal administration of EVs secreted by HBEC reduced P. aeruginosa lung burden and several pro-inflammatory cytokines including IFN-γ, TNF-α, and MIP-1β in bronchoalveolar fluid (BALF), even in the absence of antibiotics. Moreover, EVs decreased neutrophils in BALF. Thus, EVs secreted by HBEC reduce the lung burden of P. aeruginosa, decrease inflammation and reduce neutrophils in a CF mouse model. These results suggest that HBEC via the secretion of EVs may play an important role in the immune response to P. aeruginosa lung infection.PMID:38084406 | DOI:10.1152/ajplung.00253.2023
Source: Am J Physiol Lung Ce... - Category: Respiratory Medicine Authors: Source Type: research