Integration of proteomics and metabolomics reveals energy and metabolic alterations induced by glucokinase (GCK) partial inactivation in hepatocytes

In conclusion, GCK knockdown reduced TCA cycle flux and oxidative stress in hepatocytes by influencing the levels of key transcription factors and enzymes, providing a comprehensive understanding of the effects of GCK partial inactivation on liver metabolism and molecular mechanisms.PMID:38092300 | DOI:10.1016/j.cellsig.2023.111009

Source: Cellular Signalling - December 13, 2023 Category: Cytology Authors: Ziyan Xie Jieying Liu Ting Xie Peng Liu Xiangyi Hui Qian Zhang Xinhua Xiao Source Type: research