Associations between CD70 methylation of T cell DNA and age in adults with systemic lupus erythematosus and population controls: The Michigan Lupus Epidemiology & amp; Surveillance (MILES) Program

CONCLUSIONS: We describe altered CD70 methylation patterns in T lymphocyte subsets in adults with SLE relative to controls, and report associations particular to SLE between methylation of this immune-relevant gene and both age and race, possibly a consequence of "weathering" or accelerated aging which may have implications for SLE pathogenesis and potential intervention strategies.PMID:38064919 | DOI:10.1016/j.jaut.2023.103137

Source: Journal of Autoimmunity - December 8, 2023 Category: Allergy & Immunology Authors: Emily C Somers Jaclyn M Goodrich Lu Wang Sioban D Harlow Wendy Marder Afton L Hassett Suzanna M Zick W Joseph McCune Caroline Gordon Kamil E Barbour Charles G Helmick Faith M Strickland Source Type: research