Relationship between endocrine disrupting chemicals (phthalate metabolites, triclosan and bisphenols) and vitamin D in female subjects: An exploratory pilot study

CONCLUSION: These putative data indicate that MCPP is related to 25(OH)D3, while MiBP and MBP were related to vitamin D deficiency; however, no correlations were observed with TCS and BPs. No phthalate metabolites correlated with 1,25(OH)2D3, CaM associated proteins or renal function, suggesting that effects occur earlier in the vitamin D pathway and not through modulation of cellular calcium flux. The observed correlations are surprisingly strong compared to other predictors of 25(OH)D3, and larger studies adjusting for potential confounders are warranted.PMID:38070612 | DOI:10.1016/j.chemosphere.2023.140894

Source: Chemosphere - December 9, 2023 Category: Chemistry Authors: Edwina Brennan Alexandra E Butler Manjula Nandakumar Kristie Thompson Thozhukat Sathyapalan Stephen L Atkin Source Type: research