Nilotinib exhibits less toxicity than imatinib and influences the immune state by modulating iNOS, p-p38 and p-JNK in LPS/IFN gamma-activated macrophages

In conclusion, our results reveal that, in addition to its anticancer activity, nilotinib can exhibit immune modulatory effects on macrophages through its effects on iNOS, IL-6, p-p38 and p-JNK.PMID:38061604 | DOI:10.1016/j.tiv.2023.105754

Source: Toxicology in Vitro - December 7, 2023 Category: Toxicology Authors: Arzu Zeynep Karabay Tulin Ozkan Asli Koc Yalda Hekmatshoar A Selen Gurkan-Alp Asuman Sunguroglu Source Type: research