FLAER as a standalone reagent for paroxysmal nocturnal hemoglobinuria: Do we need to reconsider the guidelines for testing?

CONCLUSION: Based on our results, FLAER as a standalone marker is specific and sensitive for identifying PNH clones in granulocytes and monocytes, even for high-sensitivity PNH assay. The proposed "FLAER-only panel" panel is efficient and cost-effective for highly sensitive PNH testing in two different cell lineages, especially in resource-limited clinical settings.PMID:38069562 | DOI:10.1111/ijlh.14213

Source: International Journal of Laboratory Hematology - December 9, 2023 Category: Hematology Authors: Praveen Sharma Parveen Bose Nabhajit Mallik Dikshat Gopal Gupta Suneel Rachagiri Arun Kumar Jasbir Kaur Pankaj Malhotra Neelam Varma Man Updesh Singh Sachdeva Source Type: research