Rapid increase in salivary IgA and broad recognition of spike protein following SARS-CoV-2 vaccination

In this study, saliva samples were collected from individuals that received SARS-CoV-2 vaccine, and immunoglobulin G (IgG), IgM, and IgA against whole spike protein and S1 protein were measured. IgA against whole spike protein increased significantly following vaccination, while IgA against S1 protein did not. Of note, the IgA response was evident two weeks after the first vaccine dose and continued to rise thereafter. On the contrary, IgG antibodies against S1 increased significantly at four weeks after vaccination. These results reveal the dynamics and recognition antigens of immunoglobulins in saliva, indicating the function of IgA in the mucosal immune system. These findings may pave the way for further studies on mucosal immune response induced by vaccination.PMID:38056502 | DOI:10.1016/j.virusres.2023.199294

Source: Virus Research - December 6, 2023 Category: Virology Authors: Kenji Ota Hironori Sakai Daisuke Sasaki Fujiko Mitsumoto-Kaseida Kei Sakamoto Kosuke Kosai Hiroo Hasegawa Takahiro Takazono Koichi Izumikawa Hiroshi Mukae Mya Myat Ngwe Tun Kouichi Morita Katsunori Yanagihara Source Type: research