Anti-hepatitis C Virus Activity of Juglorubin Derivatives

In this study, the derivatives of juglorubin, 1-O-acetyljuglorubin dimethyl ester and juglorubin dimethyl ester, were found to exhibit antiviral activity against hepatitis C virus (HCV) without exerting any remarkable cytotoxicity against host Huh-7 cells. They also inhibited liver X receptor α activation and lipid droplet accumulation in Huh-7 cells. These findings suggest that 1-O-acetyljuglorubin dimethyl ester and juglorubin dimethyl ester targeted the host factors required for HCV production.PMID:37914261 | DOI:10.1248/cpb.c23-00489

Source: Chemical and Pharmaceutical Bulletin - November 1, 2023 Category: Drugs & Pharmacology Authors: Hirofumi Ohashi Kazane Nishioka Tomoki Kurihara Kou Nakamura Masako Yamasaki Yuuka Ibayashi Kanta Fuchiyama Shogo Kamo Yuuki Furuyama Kenji Ohgane Maiko Okada Shinji Kamisuki Koichi Watashi Kouji Kuramochi Source Type: research