Multilamellated basement membranes in the capillary network of alveolar capillary dysplasia

This study provides insight into the ultrastructure and pathophysiology of ACD. The lack of normally developed lung capillaries seems to cause a replacement by COL15A1+ vessels, a mechanism recently described in interstitial lung disease. The VIT loss and FN1 overexpression might contribute to the unique appearance of basement membranes in ACD. Future studies are needed to explore the therapeutic potential of downregulating the expression of FN1 and balancing of VIT deficiency.PMID:38029923 | DOI:10.1016/j.ajpath.2023.10.012

Source: Am J Pathol - November 29, 2023 Category: Pathology Authors: Jan C Kamp Lavinia Neubert Jonas C Schupp Peter Braubach Christoph Wrede Florian Laenger Tim Salditt Jakob Reichmann Tobias Welte Arjang Ruhparwar Fabio Ius Nicolaus Schwerk Anke K Bergmann Sandra von Hardenberg Matthias Griese Christina Rapp Karen M Olss Source Type: research