Mobilizable plasmids drive the spread of antimicrobial resistance genes and virulence genes in Klebsiella pneumoniae

ConclusionsOur work observed that a mobilizable MDR or virulence plasmid that carriesoriT but lacks the relaxase genes transferred with the helper CR conjugative plasmid and mobilizable plasmids escaped from CRISPR –Cas defence and remained stable in recipients. These results highlight the threats of mobilizable plasmids as vital vehicles in the dissemination of antibiotic resistance and virulence genes inK. pneumoniae.
Source: Genome Medicine - Category: Genetics & Stem Cells Source Type: research