Proteomic analysis of salivary inflammatory biomarkers of developmental gingival enlargements in patients with West and Noonan syndromes: a preliminary pilot single-center retrospective study

CONCLUSIONS: West and Noonan's syndromes showed the overexpression of molecular biomarkers involved in the pathogenesis of chronic periodontitis. The inflammatory status is triggered and amplified by the abnormal overgrowth of gingival tissues, the amplified release of proinflammatory cytokines from the immune cells, and the poor cooperation in maintaining adequate oral hygiene.PMID:38039040 | DOI:10.26355/eurrev_202311_34478

Source: Pharmacological Reviews - December 1, 2023 Category: Drugs & Pharmacology Authors: F Guglielmi F Kirschner E Staderini F Iavarone A Fiorino P Gallenzi Source Type: research