AM1172 (a hydrolysis-resistant endocannabinoid analog that inhibits anandamide cellular uptake) reduces the viability of the various melanoma cells, but it exerts significant cytotoxic effects on healthy cells: an in vitro study based on isobolographic analysis

CONCLUSIONS: AM1172 cannot be used separately as a chemotherapeutic drug, but it can be combined with PACX, DOCX, MTX, and CDDP, offering additive interactions in terms of the anti-proliferative effects in various malignant melanoma cell lines.PMID:38019413 | DOI:10.1007/s43440-023-00557-2

Source: Pharmacological Reports - November 29, 2023 Category: Drugs & Pharmacology Authors: Pawe ł Marzęda Paula Wr óblewska-Łuczka Magdalena Florek- Łuszczki Agnieszka G óralczyk Jarogniew J Łuszczki Source Type: research