Association of clinicopathologic and molecular factors with the occurrence of positive margins in breast cancer

ConclusionThe occurrence of positive margins after surgery was associated with various clinical factors, similar to the findings reported in earlier studies. In addition, we found that the PAM50 intrinsic subtype Luminal A has more chance of obtaining positive margins compared to Basal type. As the first effort to pursue molecular understanding of the margin status, a gene panel of 29 genes including 17 protein-coding genes was also identified for potential prediction of the margin status which needs to be validated using a larger sample set.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research