Thiamine analogues featuring amino-oxetanes as potent and selective inhibitors of pyruvate dehydrogenase

In this study, we show that an amino-oxetane bioisostere of the amide improves the affinity and maintains stability towards esterase-catalysed hydrolysis.PMID:38036274 | DOI:10.1016/j.bmcl.2023.129571

Source: Bioorganic and Medicinal Chemistry Letters - November 30, 2023 Category: Chemistry Authors: Alex H Y Chan Terence C S Ho Finian J Leeper Source Type: research