Arachidonic and Docosahexaenoic Acid Supplementation and Brain Maturation in Preterm Infants; a double blind RCT

&Aim: Arachidonic acid (ARA) and docosahexaenoic acid (DHA) are important structural components of neural cellular membranes and possess anti-inflammatory properties. Very preterm infants are deprived of the enhanced placental supply of these fatty acids, but the benefit of postnatal supplementation on brain development is uncertain. The aim of this study was to test the hypothesis that early enteral supplementation with ARA and DHA in preterm infants improves white matter (WM) microstructure assessed by diffusion-weighted MRI at term equivalent age.

Source: Clinical Nutrition - November 28, 2023 Category: Nutrition Authors: Sissel J. Moltu, Tone Nordvik, Madelaine E. Rossholt, Kristina Wendel, Maninder Chawla, Andres Server, Gunnthorunn Gunnarsdottir, Are Hugo Pripp, Magnus Domell öf, Marianne Bratlie, Marlen Aas, Petra S. Hüppi, Alexandre Lapillonne, Mona K. Beyer, Tom St Tags: Randomized Control Trials Source Type: research