Examining the impact of immunosuppressive drugs on antibody-dependent cellular cytotoxicity (ADCC) of human peripheral blood natural killer (NK) cells and gamma delta (gd) T cells

CONCLUSIONS: In conclusion, the findings show that despite differences in the expression levels of CD16, γδT cells like NK cells can be readily activated by engagement with RTX and that in vitro exposure to CsA and TAC (calcineurin inhibitors) had a measurable effect on cytokine production but not degranulation by both NK cells and gdT cells from healthy donors. Finally the observation that in PBMC obtained from LTx recipients, NK cells but not γδT cells exhibited impaired cytokine reponses suggests that transplantation or chronic exposure to ISDs differentially impacts their potential to respond to the introduction of an allograft and/or transplant-associated infections.PMID:38007172 | DOI:10.1016/j.trim.2023.101962

Source: Transplant Immunology - November 25, 2023 Category: Transplant Surgery Authors: Sedigheh Jalali Sanda Stankovic Glen P Westall Patrick C Reading Lucy C Sullivan Andrew G Brooks Source Type: research