Evaluation of non-thyroidal illness syndrome in shock patients admitted to pediatric intensive care unit in a developing country

Conclusion: This study underscores the high prevalence of NTI in PICU shock patients and suggests monitoring thyroid hormone levels for outcome prediction and treatment guidance. Further research is needed to optimize NTI management in critically ill children.What is Known:• Non-thyroidal illness syndrome (NTIS) is a condition observed in critically ill patients.• There has been limited research on NTI in children, and existing studies have generated conflicting results regarding the relationship between thyroid hormones and clinical outcomes in cases of sepsis and septic shock.What is New:• The study has revealed dynamic changes in free triiodothyronine (FT3) levels during the process of shock reversal and recovery in children who experienced shock.• A significant negative correlation was found between the Pediatric Index of Mortality 2 (PIM2) score and several thyroid hormone levels, including FT3 on admission and T4, FT3, and FT4 on shock reversal.
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research