Heteromeric formation with {beta}A3 protects the low thermal stability of {beta}B1-L116P

Conclusions Decreased βB1-crystallin thermal stability in the presence of the cataract-related L116P mutation contributes significantly to congenital cataract formation. Moreover, its formation of heteromers with βA3 protects against the low thermal stability of βB1-L116P.
Source: British Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Original articles - Laboratory science Source Type: research