Heteromeric formation with {beta}A3 protects the low thermal stability of {beta}B1-L116P
Conclusions
Decreased βB1-crystallin thermal stability in the presence of the cataract-related L116P mutation contributes significantly to congenital cataract formation. Moreover, its formation of heteromers with βA3 protects against the low thermal stability of βB1-L116P.
Source: British Journal of Ophthalmology - Category: Opthalmology Authors: Xu, J., Zhang, Y., Liu, J., Hu, L., Luo, C., Yao, K., Chen, X. Tags: Original articles - Laboratory science Source Type: research
More News: Blindness | Cataracts | Disability | Laboratory Medicine | Opthalmology | Science | Study | UK Health