When you eat and when you sleep matters: circadian dysfunction revealed as a direct hepatic carcinogen in a humanized mouse model

Yes, WHEN you sleep and WHEN you eat matters, and it has a direct impact on the health of your liver. Abundant literature over the last two decades supports this tenet 1 –7. Certainly, multiple indirect evidences ranging from epidemiological data to mouse models of circadian gene deficiency or induction of circadian disruption, have been provided on the role of circadian rhythm disturbances, including jet-lag, shift work and unhealthy lifestyle, in the development of chronic liver disease and hepatocellular carcinoma (HCC).
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Editorial Source Type: research