Glucagon-like peptide-1 receptor blockade impairs islet secretion and glucose metabolism in humans

CONCLUSION These data show that GLP1R blockade impairs islet function, implying that intra-islet GLP1R activation alters islet responses to glucose and does so to a greater degree in people with type 2 diabetes.TRIAL REGISTRATION This study was registered at ClinicalTrials.gov NCT04466618.FUNDING The study was primarily funded by NIH NIDDK DK126206. AV is supported by DK78646, DK116231 and DK126206. CDM was supported by MIUR (Italian Minister for Education) under the initiative “Departments of Excellence” (Law 232/2016).

Source: Journal of Clinical Investigation - November 15, 2023 Category: Biomedical Science Authors: Andrew A. Welch, Rahele A. Farahani, Aoife M. Egan, Marcello C. Laurenti, Maya Zeini, Max Vella, Kent R. Bailey, Claudio Cobelli, Chiara Dalla Man, Aleksey Matveyenko, Adrian Vella Source Type: research