Dissecting the biophysics and biology of intrinsically disordered proteins

Trends Biochem Sci. 2023 Nov 8:S0968-0004(23)00257-8. doi: 10.1016/j.tibs.2023.10.002. Online ahead of print.ABSTRACTIntrinsically disordered regions (IDRs) within human proteins play critical roles in cellular information processing, including signaling, transcription, stress response, DNA repair, genome organization, and RNA processing. Here, we summarize current challenges in the field and propose cutting-edge approaches to address them in physiology and disease processes, with a focus on cancer.PMID:37949765 | DOI:10.1016/j.tibs.2023.10.002

Source: Trends in Biochemical Sciences - November 10, 2023 Category: Biochemistry Authors: Priya R Banerjee Alex S Holehouse Richard Kriwacki Paul Robustelli Hao Jiang Alexander I Sobolevsky Jennifer M Hurley Joshua T Mendell Source Type: research