Pyrrole: A decisive scaffold for the development of therapeutic agents and structure-activity relationship

ChemMedChem. 2023 Nov 5:e202300447. doi: 10.1002/cmdc.202300447. Online ahead of print.ABSTRACTThe overview of pyrroles as distinct scaffolds with therapeutic potential and the significance of pyrrole derivatives for drug development are provided in this article. It lists instances of naturally occurring pyrrole-containing compounds and describes the sources of pyrroles in nature, including plants and microbes. It also explains the many conventional and modern synthetic methods used to produce pyrroles. The key topics are the biological characteristics, pharmacological behavior, and functional alterations displayed by pyrrole derivatives. It also detailed how pyrrole is used to treat infectious diseases. It delivered a description of infectious disorders resistant to standard treatments and discussed the function of compounds containing pyrroles in combating infectious diseases. Furthermore, the review covers the uses of pyrrole derivatives in treating non-infectious diseases and resistance mechanisms in non-infectious illnesses like cancer, Alzheimer's, diabetes, and Parkinson's. The important discoveries and probable avenues for pyrrole research were finally summarized, and their significance for medicinal chemists and drug development. A reference from the last two decades is included in this review.PMID:37926686 | DOI:10.1002/cmdc.202300447

Source: ChemMedChem - November 5, 2023 Category: Chemistry Authors: Bharathi Hassan Ganesh Anirudh G Raj Baladhandapani Aruchamy Pandurangan Nanjan Carmelo Drago Prasanna Ramani Source Type: research