PDGFR β signaling cooperates with β-catenin to modulate c-Abl and biologic behavior of desmoid-type fibromatosis

CONCLUSIONS: The β-catenin transcriptional target ABL1 is necessary for proliferation and maintenance of HIF1α in desmoid cells. Regulation of c-Abl activity by PDGF signaling and targeted therapies modulates desmoid cell proliferation, thereby suggesting a reason for variable biologic behavior between tumors, a mechanism for sorafenib activity in desmoids, and markers predictive of outcome in patients.PMID:37943631 | DOI:10.1158/1078-0432.CCR-23-2313

Source: Cell Research - November 9, 2023 Category: Cytology Authors: Jia Hu Meera R Hameed Narasimhan P Agaram Karissa A Whiting Li-Xuan Qin Anthony M Villano Rachael B O'Connor Julian M Rozenberg Sonia Cohen Katherine Prendergast Sara Kryeziu Richard L White Mitchell C Posner Nicholas D Socci Mrinal M Gounder Samuel Singe Source Type: research