Selective Inhibition of Hepatic Stellate Cell and Fibroblast-derived LOXL1 Attenuates BDL and Mdr2 < sup > -/- < /sup > Induced Cholestatic Liver Fibrosis

CONCLUSION: Our findings demonstrated that selective inhibition of LOXL1 derived from HSCs/fibroblasts attenuated cholestatic liver/biliary fibrosis, inflammation, ductal reaction, and HSC/fibroblast proliferation. Based on our findings LOXL1 could be a potential therapeutic target for cholestatic fibrosis.PMID:37873581 | DOI:10.1152/ajpgi.00004.2023

Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - October 24, 2023 Category: Physiology Authors: Xuzhen Yan Ning Zhang Luyang Wei Wen Zhang Tao Huang Weiyu Li Wei Chen Aiting Yang Hong You Source Type: research