Protein Dynamics Mediated by Cardiolipin in Bacteria

Curr Top Med Chem. 2023 Oct 27. doi: 10.2174/0115680266266646231023091215. Online ahead of print.ABSTRACTBacterial proteins targeting the appropriate subcellular sites are the base for their proper function. Several studies have shown that the anionic phospholipid cardiolipin (CL), a conical lipid preferring negative membrane curvature, modulates the lipid bilayers' structure, which impacts the activity of their resident proteins. Due to the favor of negative membrane curvature, CL is not randomly distributed in the bacterial plasma membrane. In contrast, it gathers in particular parts of the cell membrane to form microdomains, in which many functional membrane proteins are accumulated and carry out diverse physiological processes of bacteria, such as cell division, metabolism, infection, and antibiotic residence. In addition, CL has a unique structure that carries two negative charges, which makes it play a pivotal role in protein assembly, interaction, and location. These characteristics of CL make it closely related to many crucial physiological functions of bacteria. Here, we have reviewed the mechanism of protein dynamics mediated by CL initiated on the bacterial membrane. Furthermore, we studied the effect of CL on bacterial infection and antibiotic residence. Finally, the CL-targeting therapeutic agents for antibacterial therapy are also examined.PMID:37929725 | DOI:10.2174/0115680266266646231023091215

Source: Current Topics in Medicinal Chemistry - November 6, 2023 Category: Chemistry Authors: Yanyang Wang Jiawen Chen Liyang Hang Jichao Zhu Xinhua Qiang Mingjian Yang Xiangliang Sun Sha Wang Hongchang Zhou Yibin Lin Shengwen Shao Source Type: research