202 Increased circulating IL-17+ TRM are associated with Squamous Cell Carcinoma in Patients with Recessive Dystrophic Epidermolysis Bullosa

Epidermolysis bullosa (EB) is a group of rare genetic skin disorders with mutations in genes responsible for mucocutaneous structural integrity. Even minor mechanical insults results in blistering of skin and mucous membranes. Patients with recessive EB (RDEB), a severe form of EB, often develop Squamous Cell Carcinomas (SCC), which are typically more aggressive compared to SCC in non-EB patients. SCC in EB patients typically arise in regions with inflamed chronical skin wounds. We thus hypothesize that cutaneous inflammation is promoting SCC tumors.

Source: Journal of Investigative Dermatology - November 1, 2023 Category: Dermatology Authors: A. Sharma, S. Zaafouri, S.R. Varkhande, M.M. Klicznik, G. Nasi, K. Umundum, M. Lew, A. Sophianidis, L.C. Sch öftner, A. Gerstenberger, E.M. Murauer, J.P. Hofbauer, C. Guttmann-Gruber, N. Fortelny, V. Wally, D.J. Campbell, I.K. Gratz Source Type: research