Talin mechanotransduction in disease

Int J Biochem Cell Biol. 2023 Oct 30:106490. doi: 10.1016/j.biocel.2023.106490. Online ahead of print.ABSTRACTTalin protein (Talin 1/2) is a mechanosensitive cytoskeleton protein. The unique structure of the Talin plays a vital role in transmitting mechanical forces. Talin proteins connect the extracellular matrix to the cytoskeleton by linking to integrins and actin, thereby mediating the conversion of mechanical signals into biochemical signals and influencing disease progression as potential diagnostic indicators, therapeutic targets, and prognostic indicators of various diseases. Most studies in recent years have confirmed that mechanical forces also have a crucial role in the development of disease, and Talin has been found to play a role in several diseases. Still, more studies need to be done on how Talin is involved in mechanical signaling in disease. This review focuses on the mechanical signaling of Talin in disease, aiming to summarize the mechanisms by which Talin plays a role in disease and to provide references for further studies.PMID:37914021 | DOI:10.1016/j.biocel.2023.106490
Source: The International Journal of Biochemistry and Cell Biology - Category: Biochemistry Authors: Source Type: research