Synthesis and Biological Evaluation of Oxindole Sulfonamide Derivatives as Bruton's Tyrosine Kinase Inhibitors

This study focuses on the design and synthesis of new oxindole sulfonamide derivatives as promising inhibitors of BTK with negligible off-target effects. The most cytotoxic compounds with greater basicity were PID-4 (2.29 ± 0.52 µM), PID-6 (9.37 ± 2.47 µM), and PID-19 (2.64 ± 0.88 µM). These compounds caused a selective inhibition of Burkitt's lymphoma RAMOS cells without significant cytotoxicity in non-BTK cancerous and non-cancerous cell lines. Further, PID-4 showed promising activity in inhibiting BTK and downstream signalling cascades. As a potent inhibitor of Burkitt's lymphoma cells, PID-4 is a promising lead for developing novel chemotherapeutics.PMID:37916435 | DOI:10.1002/cmdc.202300511

Source: ChemMedChem - November 2, 2023 Category: Chemistry Authors: Chandra Prakash Koraboina Venkatanarayana Chowdary Maddipati Narendran Annadurai So ňa Gurská Petr Dzubak Marian Hajduch Viswanath Das Rambabu Gundla Source Type: research