Phenotypic and Functional Diversity of Neutrophils in Gut Inflammation and Cancer

Am J Pathol. 2023 Oct 31:S0002-9440(23)00416-9. doi: 10.1016/j.ajpath.2023.10.009. Online ahead of print.ABSTRACTNeutrophils (PMNs) execute important effector functions protecting the host against invading pathogens, however their activity in tissue can exacerbate inflammation and inflammation-associated tissue injury and tumorigenesis. Until recently PMN were considered to be short-lived, terminally differentiated phagocytes, however this view is rapidly changing with the emerging evidence of increased PMN lifespan in tissues, PMN plasticity and phenotypic heterogeneity. Specialized PMN subsets have been identified in inflammation and in developing tumors consistent with both beneficial and detrimental functions of PMNs in these conditions. Since PMN and tumor associated neutrophil (TAN) activity and the resulting beneficial/detrimental impacts primarily occur after homing to inflamed tissue/tumors, studying the underlying mechanisms of PMN/TAN trafficking is of high interest and clinical relevance. This review will summarize some of the key findings from over a decade of work from our laboratory and others on the regulation of PMN recruitment and identification of phenotypically and functionally diverse PMN subtypes as it pertains to gut inflammation and colon cancer.PMID:37918801 | DOI:10.1016/j.ajpath.2023.10.009
Source: Am J Pathol - Category: Pathology Authors: Source Type: research