Ion homeostasis in diabetic kidney disease

Trends Endocrinol Metab. 2023 Oct 23:S1043-2760(23)00211-4. doi: 10.1016/j.tem.2023.09.009. Online ahead of print.ABSTRACTThe complications of type 2 diabetes are a major global public health problem with high incidence and mortality, affecting almost all individuals with diabetes worldwide. Diabetic kidney disease (DKD) is one such primary complication and has become a leading cause of end-stage renal disease in patients with diabetes. Progression from diabetes to DKD is a complex process typically involving multiple mechanisms. Recent remarkable clinical benefits of sodium-glucose cotransporter 2 (SGLT2) inhibitors in diabetes and DKD highlight the critical impact of renal ion homeostasis on disease progression. This review comprehensively examines the impact of ion homeostasis on the transition from diabetes to DKD, outlining possible therapeutic interventions and addressing the ongoing challenges in this rapidly developing field.PMID:37880052 | DOI:10.1016/j.tem.2023.09.009
Source: Trends in Endocrinology and Metabolism: TEM - Category: Endocrinology Authors: Source Type: research